PEESE, Kevin,WANG, Zhongyu,KADOW, John F.,NAIDU, B. Narasimhulu
申请号：
ES14725559
公开号：
ES2623777T3
申请日:
2014.03.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I in which: R1 is -CON (R7) (R8), -NHSOR7 or (R7) Ar2； R2 is hydrogen or alkyl； R3 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, haloxyalkoxy, haloxyalkoxy, haloxy ； or R3 is cycloalkyl, cycloalkenyl, chromanyl, oxazinyl or dihydropyranquinolinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy alkenyloxy and phenyl； R4 is alkyl or haloalkyl； R5 is hydrogen or alkyl； R6 is hydrogen or alkyl； R7 is Ar1 or (Ar1) alkyl； R8 is hydrogen or alkyl； Ar1 is phenyl substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy and alkenyloxy； and Ar2 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl or thiadiazolyl, and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy and alkenyl ； or a pharmaceutically acceptable salt thereof, wherein alkyl means a linear or branched alkyl group composed of 1 to 6 carbons； alkenyl means a linear or branched alkyl group consisting of 2 to 6 carbons with at least one double bond； cycloalkyl means a monocyclic ring system composed of 3 to 7 carbons； and hydroxyl and alkyl include linear and branched isomers composed of 1 to 6 carbon atoms for the alkyl moiety.Un compuesto de Fórmula I en la que: R1 es -CON(R7)(R8), -NHSOR7 o (R7)Ar2； R2 es hidrógeno o alquilo； R3 es azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, homopiperidinilo, homopiperazinilo u homomorfolinilo, y está sustituido con 0-3 sustituyentes seleccionados entre halo, alquilo, haloalquilo, hidroxialquilo, alcoxialquilo, alquenilo, cicloalquilo, hidroxi, alcoxi, haloalcoxi alquen
