PURPOSE: A complex produced by a polycaprolactone biopolymer/bioactive glass spherical particle complex production method is provided to be used in various fields of bone histology as the complex has excellent mechanical property and biological characteristic. CONSTITUTION: A complex produced by a polycaprolactone biopolymer/bioactive glass spherical particle complex production method comprises a bioactive glass spherical particle and a biopolymer. The porosity of the spherical particle complex is 11-19%. Bioactive glass includes a mixture of tetraethyl orthosilicate, triethylphosphate, and calcium nitrate. The biopolymer is polycaprolactone(PCL), polylactic acid(PLA), or polylactic glycolc acid (PLGA). The production method of the biopolymer/bioactive glass spherical particle complex includes producing complex slurry by mixing a bioactive glass spherical particle and the biopolymer into a solvent, and removing the solvent in the complex slurry. [Reference numerals] (AA) Bioactive glass spherical particle solution； (BB,KK) Drying； (CC) Heat-treating； (DD) Bioactive glass spherical particle； (EE) Ultrasound vibration； (FF) Bioactive glass spherical particle uniformly dispersed in DCM； (GG) Add PCL； (HH) Dissolve PCL； (II) PCL/bioactive glass spherical particle solution； (JJ) Casting； (LL) PCL/bioactive glass spherical particle complex본 발명은 (생체활성유리 구형입자 및 생체고분자를 포함하는 생체고분자/생체활성유리 구형입자 복합체에 관한 것이다.본 발명에 따른 생체고분자/생체활성유리 구형입자 복합체는 우수한 기계적 물성과 생물학적 특성을 가지므로, 뼈 조직 공학의 다양한 영역에서 유용하게 사용될 수 있다.
