PROBLEM TO BE SOLVED: To provide an anti-inflammatory agent that allows macrophages to migrate to an inflammation site, and can increase the production amount of interleukin 10 (IL-10), which induces an anti-inflammatory action.SOLUTION: An anti-inflammatory agent contains a polypeptide (A) having at least one amino acid sequence selected from the group consisting of VGVPG sequence (1), GVGVP sequence (2) and VPGVG sequence (3) of 1-200 in total, and/or a polypeptide (A) having an amino acid sequence with a homology of 85% or more to the amino acid sequence of the polypeptide (A).SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】マクロファージを炎症部位に遊走させ、抗炎症作用を誘導するインターロイキン10(IL-10)の産生量を増加させることができる抗炎症剤を提供する。【解決手段】VGVPG配列(1)、GVGVP配列(2)及びVPGVG配列(3)からなる群より選ばれる少なくとも1種のアミノ酸配列を合計1~200個有するポリペプチド(A)及び/又は前記ポリペプチド(A)のアミノ酸配列との相同性が85%以上のアミノ酸配列を有するポリペプチド(A’)を含有する抗炎症剤。【選択図】なし
