PROCEDURES FOR THE RECOVERY OF THE IMMUNE REPERTOIR IN PATIENTS WITH IMMUNOLOGICAL DEFECTS RELATING TO AUTO-IMMUNITY AND TRANSPLANTATION OF ORGANS OR HEMATOPOEITIC STEM CELLS
The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g. autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
