КНИСЛИ Кейт А. (US),МАРЛА Вишну Т. (US),РЭДСПИННЕР Рейчел (US),СИЛЬВАНИ Пол А. (US),СТРИД Джейсон Дж. (US),ВОНЕШ Майкл Дж. (US)
申请号：
RU2014139913
公开号：
RU2014139913A
申请日:
2013.02.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A blood contact surface containing a polytetrafluoroethylene microstructure of nodes and fibers, both in the x direction and in the substantially perpendicular direction y； in which the nodes and fibers have an average distance between adjacent nodes of 5 μm or less； and in which the average width of the 32 largest nodes in a representative micrograph taken at 10,000 times with a scanning electron microscope is less than about 1.5 microns. 2. The surface of claim 1, wherein the nodes and fibers have a ratio of average distances between adjacent nodes in the x and y directions from about 2: 1 to 1: 1.3. The surface of claim 2, wherein the ratio of the average distances between adjacent nodes in the x and y directions is about 1: 1.4. The surface of claim 1, wherein the expanded polytetrafluoroethylene contains polytetrafluoroethylene expanded in many axes. The surface of claim 4, wherein the expanded polytetrafluoroethylene contains two-axis extended polytetrafluoroethylene. The surface of claim 1, wherein the expanded polytetrafluoroethylene contains fibers extending outward from the nodes in substantially perpendicular directions. The surface of claim 1, wherein the average width of the nodes is less than about 1.25 microns. A surface according to claim 1, in which the average width of the nodes is less than about 1 μm. A surface according to claim 1, wherein the ratio of the average distances between adjacent nodes in the x and y directions is less than 1.5: 1.10. The surface of claim 1, wherein the microstructure substantially prevents cell growth. The surface of claim 1, which is integrated in an implantable medical device. 12. The surface of claim 1, which is embedded in non-implantable medical devices1. Поверхность контакта с кровью, содержащаяполитетрафторэтиленовую микроструктуру из узлов и волокон, как в направлении x, так и в, по существу, перпендикулярном направлении y；в которой узлы и волокна имеют среднее расстояние между соседними узлами, составляющ
