The composition, and pharmaceutical applications and manufacturing methods and II crystalline form I of monohydrate (R) -7- chloro -N- (quinuclidine-3-yl) benzo [b] thiophene-2-carboxamide hydrochloride is described is. [Selection Figure Figure 5(R)-7-クロロ-N-(キヌクリジン-3-イル)ベンゾ[b]チオフェン-2-カルボキサミド塩酸塩一水和物の結晶形I及びII並びにその組成物、製造方法及び医薬用途が記載される。【選択図】図5