Chang-Sun Lee,Ramil Baiazitov,Liangxian Cao,Thomas W Davis,Wu Du,Ronggang Liu,Young-choon Moon,Steven D. Paget,Hongyu Ren,Nadiya Sydorenko,Richard Gerald Wilde
申请号：
US14443911
公开号：
US10428050B2
申请日:
2013.11.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
