CUMMINGS, Craig Anthony,LI, Yan,PAUL, Sarah Margaret,SCHLEIFMAN, Erica Beth,SHAMES, David,FABRIZIO, David,LIEBER, Daniel,OTTO, Geoffrey Alan,KENNEDY, Mark,CLARK, Travis,LIPSON, Doron,HE, Jie,ZHONG, Sh
申请号：
AU2018304458
公开号：
AU2018304458A1
申请日:
2018.07.20
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.
