Craig Anthony CUMMINGS,Yan LI,Sarah Margaret PAUL,Erica Beth SCHLEIFMAN,David SHAMES,David FABRIZIO,Daniel LIEBER,Geoffrey Alan OTTO,Mark KENNEDY,Travis CLARK,Doron LIPSON,Jie HE,Shan ZHONG
申请号：
US16041363
公开号：
US20190025308A1
申请日:
2018.07.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.
