AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE

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专利权人:

PIRAMAL ENTERPRISES LIMITED

发明人:

Milind GHARPURE,Ashutosh JAGTAP,Changdev RAUT,Nainesh KANSAGARA,Jaisankar KRISHNAPILLAI,Nirmal Kumar MANOHARAN,Navnath PATIL

申请号：

US16088196

公开号：

US20200299227A1

申请日:

2017.03.28

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) (Droxidopa) and its salts； comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (h) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.

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