Manufacturing dentures for a patient includes preparing a dentition plan； designing dentures based on the dentition plan； and fabricating the dentures. To fabricate the dentures, one or more patterns of the dentures may be produced, tooth substitutes may be assembled on the pattern, and one or more denture bases may be cast around the tooth substitutes from the patterns. Alternatively, tooth substitutes may be installed on denture bases that are milled or otherwise fabricated. The roots of the tooth substitutes may be modified to better fit in the designed dentures.
