Disclosed are a DNA oxidative damage repairing device and an application method thereof. The device is composed of an electronic emitting assembly, an electronic emitting electrode, a control system, a power source, a support and the like. The device emits electrons to a space in a certain range, negatively charged nano particles with certain density are formed in the space, the space is sterilized, and various hazardous substances in suspension space are eliminated. The negatively charged nano particles entering a body through a respiratory system release electrons carried by the particles, electrons lost due to oxidative damage are replenished to all parts of the body, and dormant state genes can also be repaired and activated. The two-way regulation function can play a role in broad spectrum medical treatment, so that diseases that cannot be cured through drugs easily at present are cured. The device has an obvious curative effect on diseases caused by immune function deficiencies, diseases of a respiratory system, various wounds, diseases caused by drug addiction treatment and the like. The method is combined with correct and effective using of suppressing drugs and accurate using of traditional Chinese medicine, and accordingly a novel hopeful therapeutic scheme for treating AIDS, cancers and various genetic diseases before histone codes are deciphered can be provided.Linvention concerne un dispositif de réparation de dommage doxydation dADN et son procédé dapplication. Le dispositif est composé dun ensemble démission électronique, dune électrode démission électronique, dun système de commande, dune source dénergie, dun support et analogue. Le dispositif émet des électrons à un espace dans une certaine plage, des nanoparticules chargées négativement ayant une certaine densité sont formées dans lespace, lespace est stérilisé, et diverses substances dangereuses sont éliminées dans un espace en suspension. Les nanoparticules chargées négativement, entrant dans un