Platinum complexes of malonic acid derivatives in which the leaving group contains an amino group or an alkylamino group, and preparation methods and applications thereof
Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.本発明は、脱離基がアミノ基、アルキルアミノ基を含むマロン酸誘導体の白金化合物及びその薬学的に許容される塩、その製造方法及び上記化合物を含む医薬組成物を開示している。本発明は、また、上記化合物の細胞増殖性疾患の治療、特に癌の治療における用途を開示している。本発明の白金化合物は、水溶性が高く、毒性が低い。【選択図】なし
