Disclosed is a method for producing a membrane vesicle composition, the method comprising a step for treating bacteria and/or fungi with artepillin C to produce a membrane vesicle in said bacteria and/or fungi.本發明揭示一種膜囊泡組合物之製造方法,該膜囊泡組合物之製造方法包含利用阿特匹林C對細菌及/或菌類進行處理而使該細菌及/或菌類產生膜囊泡之步驟。