FRANK-KAMENETSKY, Maria D.,YANG, Hailin,MORRIS, Aaron,VARGEESE, Chandra,FRANCIS, Christopher J.
申请号：
HK18114508
公开号：
HK1255369A1
申请日:
2018.11.14
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.
