VARGEESE CHANDRA,MEENA,SVRZIKAPA NENAD,MOHAPATRA SUSOVAN,FRANCIS CHRISTOPHER J,VERDINE GREGORY L,SOKOLOVSKA ANNA
申请号：
IN201817000480
公开号：
IN201817000480A
申请日:
2018.01.04
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Among other things the present disclosure relates to chirally controlled oligonucleotides of select designs chirally controlled oligonucleotide compositions and methods of making and using the same. In some embodiments a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments a chirally controlled oligonucleotide composition has any sequence of bases and/or pattern or base modifications sugar modifications backbone modifications and/or stereochemistry or combination of these elements described herein.
