A goal module (78, 198, 298) includes one or more content sessions (80, 82, 200, 202, 204, 224, 300, 318) cooperatively directed toward achieving a projected health management goal. At least one feedback path (48, 86, 140, 142, 210, 234, 312, 322, 410) provides at least one input indicative of a trend in a patient progress toward achieving the projected health management goal. A care plan manager (84) dynamically configures or modifies at least one of the goal module (78, 198, 298) and content sessions (80, 82, 200, 202, 204, 224, 300, 318) based at least on the one input and intervention rules so that the patient's progress toward the projected health management goal is optimized.