Compound of formula I: ** Formula ** in which: R1 is selected from the group consisting of H, C1-8 alkyl optionally substituted with one or more fluorine atoms, C1-3 alkylene-C6-10 aryl, C1-3 alkyl-C1-9 heteroaryl, C3-7 cycloalkyl, C2-3-OH alkyl, - [(CH2) 2O] 1-3CH3, C1-6-OC alkylene (O) R20, C1-6-NR21R22 alkyl , -CH2CH (NH2) -COOCH3, C1-6-C alkylene (O) R23, C0-6-morpholine alkyl, C1-6-SO2-alkyl C1-6 alkyl, ** Formula ** in which R20 is selected from the group consisting of C1-6 alkyl, -O-C1-6 alkyl, C3-7 cycloalkyl, -O3-7 cycloalkyl, phenyl, -O-phenyl, -NR21R22, -CH (R25) -NH2 , -CH (R25) -NHC (O) O-C1-6 alkyl and -CH (NH2) CH2COOCH3, and R21 and R22 are independently selected from the group consisting of H, C1-6 alkyl and benzyl, or R21 and R22 together form - (CH2) 3-6-, -C (O) - (CH2) 3- or - (CH2) 2O (CH2) 2-； R23 is selected from the group consisting of -O-C1-6 alkyl, -O-benzyl and -NR21R22； R24 is C1-6 alkyl or C0-6 alkyl-C6-10 aryl and R25 is H, -CH3, -CH (CH3) 2, phenyl or benzyl, R2 is -OH, -CH2OH or -CH2-O-C1 alkyl -6 and R3 is H or -CH3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, -OH, -CH3, -OCH3, -CN and -CF3, X is H, -C (O ) -R6, -C (O) -NR7R8, -C (O) -NR9-NR10R11, -C (O) -NR12-NR13-C (O) -R14 or -CH (R15) -OR16, R6 is alkyl C1-6, C1-6 alkyl-O-C1-6 alkyl, C6-10 aryl, benzyl or C1-9 heteroaryl, R7 is H, -OH or C1-6 alkyl, R8 is C1-6 alkyl, -O- C1-6 alkyl, C5-6 cycloalkyl, C6-10 aryl, -O-C6-10 aryl, -O-benzyl, pyridine optionally substituted with halo, -OH, C1-6 alkyl or -O-C1-6 alkyl, morpholine or isoxazolidinone, or R7 and R8 together form a ring selected from the group consisting of: ** Formula ** and in which a is 1 and R26 is -OH, or is 2 and each R26 is independently halo or - C1-3-alkylene； R27 is -C 1-3 alkyl-OH, -C (O) NH2 or -SO2CH3； b is 0, or b is 1 and R28 is -C 1-3 alkyl-OH, or b is 2 and each R28 is C 1-6 alkyl； R29 is halo, -COOH, -OH, -C1-3alkyl-OH, -CH2O-CH3, -CONH2, -CN, or pyridine； R30 is C1-6
