Baker IDI Heart and Diabetes Institute Holdings Limited;Washington State University
发明人:
Rodgers, Buel Dantese,Gregorevic, Paul
申请号：
AU2016252887
公开号：
AU2016252887A1
申请日:
2016.04.22
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Described herein are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV (rAAV) expressing Smad7. The disclosed AAV vectors and rAAV can be used for therapeutic applications in the treatment and amelioration of muscle wasting, cardiac and/or skeletal muscle wasting associated with cancer cachexia. Specifically, the rAAV construct is serotype 6 (rAAV6), serotype 8 (rAAV8), or serotype 9 (rAAV9).
