Marcos Lopez,Micael Joel Hardy,Balaraman Kalyanaraman,Ming Zhao
申请号：
US12394581
公开号：
US08388931B2
申请日:
2009.02.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
99mTc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging. 99mTc-Mito10-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared to 99mTc-MIBI. 99mTc-Mito10-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.
