您的位置: 首页 > 农业专利 > 详情页

METHOD FOR SUPPRESSING TUMOR GROWTH BY BLOCKING FIBROBLAST GROWTH FACTOR RECEPTOR, AND METHOD FOR DIAGNOSING MALIGNANT NEOPLASMS
专利权人:
发明人:
申请号:
EP09846731.9
公开号:
EP2450055A1
申请日:
2009.06.30
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The invention pertains to the field of medicine and relates to a method for suppressing the growth of tumors, which comprises blocking the pathway of "human fibroblast growth factor / human fibroblast growth factor receptor 1 (domains II and IIIc)", and to a method for diagnosing malignant neoplasms. This pathological pathway leads to an excessive proliferation of tumor cells and to the formation of new vessels accompanied by the growth of primary tumors and metastases. This pathway also represents an independent mechanism of tumor resistance to pharmaceutical preparations affecting other pathological pathways. Blocking the pathway of "fibroblast growth factor / fibroblast growth factor receptor 1" using various substances that neutralize the receptor by binding only to domains II and IIIc thereof results in the inhibition or slow-down of tumor growth. This receptor can also be used as a target for targeted delivery of diagnostic agents as it is present in large amounts in the cells of numerous tumors. The invention is advantageous in that it makes it possible to develop new agents for diagnosing and treating diseases related to excessive proliferation and neovascularization.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充