David V. Schaffer,Ryan R. Klimczak,James T. Koerber,John G. Flannery,Deniz Dalkara Mourot,Meike Visel,Leah C. T. Byrne
申请号：
US14606543
公开号：
US09856539B2
申请日:
2015.01.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
