The present invention relates to a pharmaceutical composition based on acompound of the avermectin family, in the form of a cream-gel comprising, in aphysiologically acceptable medium, an oily phase dispersed in an aqueous phaseby means of a non-surfactant polymeric emulsifier, said oily phase comprisingoils having a melting point below 30~C and being free of solid fats having amelting point above 30~C. It also relates to the process for preparing sameand to its use in the production of a pharmaceutical preparation intended forthe treatment of dermatological conditions, in particular of rosacea.