Skin disease with bladder disease of instability inflammation of the general, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disease, inflammatory eye disease, or inflammatory, psoriasis, an inflammatory component, for example, systemic lupus erythematosus (SLE), myasthenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple sclerosis, autoimmune diseases, any form, such as autoimmune hemolytic anemia and Sjogrens syndrome including allergic conditions, including hypersensitivity, and compositions containing the same, and bicyclic heteroaryl substituent for the treatment of chronic inflammatory conditions including but not limited to. The present invention is, for example, acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative disorders (MPD), chronic myelogenous leukemia (CML), T-cell acute lymphoblastic leukemia (T- including solid tumors such as breast cancer and (NHL) B-cell lymphoma leukemia, non-Hodgkins lymphoma ALL), B-cell acute lymphoblastic leukemia, such as (B-ALL), but are not limited to, p110δ activity mediated to a method of treating a cancer associated to it to enable or depend on it. None [Selection Figure]一般の炎症、関節炎、リウマチ性疾患、変形性関節症、炎症性大腸疾病、炎症性眼疾病、炎症性又は不安定性の膀胱疾病、乾癬、炎症性成分を伴った皮膚疾患、たとえば、全身性エリテマトーデス(SLE)、重症筋無力症、関節リウマチ、急性播種性脳脊髄炎、特発性血小板減少性紫斑病、多発性硬化症、シェーグレン症候群及び自己免疫性溶血性貧血のような自己免疫疾患、あらゆる形態の過敏症を含むアレルギー状態を含むが、これらに限定されない慢性の炎症状態を治療するための置換二環式ヘテロアリール及びそれを含有する組成物。本発明はまた、たとえば、急性骨髄性白血病(AML)、骨髄異形成症候群(MDS)、骨髄増殖性疾患(MPD)、慢性骨髄性白血病(CML)、T細胞急性リンパ芽球性白血病(T-ALL)、B細胞急性リンパ芽球性白血病(B-ALL)のような白血病、非ホジキンリンパ腫(NHL)B細胞リンパ腫及び乳癌のような固形腫瘍を含むが、これらに限定されない、p110δ活性が介在する、それに依存する又はそれに関連する癌を治療する方法も可能にする。【選択図】なし
