For the treatment of the following composition containing the same and bicyclic heteroaryl substituent: general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disease, inflammatory eye diseases, inflammatory unstable bladder skin diseases accompanied disorder, psoriasis, an inflammatory component, autoimmune diseases such as systemic lupus erythematosus (SLE), myasthenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple but not limited to, including autoimmune hemolytic anemia sexually sclerosis, Sjogrens syndrome and chronic inflammatory conditions, allergic conditions, including hypersensitivity all forms. The present invention also include acute myelogenous leukemia (AML) myelodysplastic syndrome (MDS) Myeloproliferative disorder (MPD) with chronic myelogenous leukemia (CML) T cell acute lymphoblastic leukemia (T-ALL) B cell acute related or mediated, but not limited to, including solid tumors, breast cancer such as leukemia and lymphocytic leukemia (B-ALL) non-Hodgkins lymphoma (NHL) B-cell lymphoma, etc. to p110 activity dependent or Method for the treatment of cancer is also possible.下記を治療するための、置換二環式ヘテロアリールおよびそれを含む組成物:一般的炎症、関節炎、リウマチ性疾患、変形性関節症、炎症性腸疾患、炎症性眼疾患、炎症性不安定膀胱障害、乾癬、炎症性要素を伴った皮膚疾患、自己免疫疾患、例えば、全身性エリテマトーデス(SLE)、重症筋無力症、関節リウマチ、急性散在性脳脊髄炎、特発性血小板減少性紫斑病、多発性硬化症、シェーグレン症候群および自己免疫性溶血性貧血を含む(これに限定されない)慢性炎症状態、あらゆる形態の過敏症を含むアレルギー状態。本発明は、また、急性骨髄性白血病(AML)骨髄異形成症候群(MDS)骨髄増殖性疾患(MPD)慢性骨髄性白血病(CML)T細胞性急性リンパ性白血病(T-ALL)B細胞性急性リンパ性白血病(B-ALL)非ホジキンリンパ腫(NHL)B細胞リンパ腫、等の白血病および乳癌等の固形腫瘍、を含む(これに限定されない)p110活性に媒介されるか、依存するか、または関連する癌の治療のための方法も可能にする。
