The present invention relates to bilayer tablet, the bilayer tablet includes melbine XR preparations, the SGLT2 inhibitor preparation as the second layer and the optional film coating being reduced as melbine extended release (XR) preparation or quality of first layer. The present invention provides the method for preparing the bilayer tablet and using bilayer tablet treatment disease relevant to SGLT2 activity or the method for obstacle.本發明涉及雙層片劑,所述雙層片劑包含作爲第一層的二甲雙胍延長釋放(XR)製劑或質量得以減小的二甲雙胍XR製劑、作爲第二層的SGLT2抑制劑製劑及任選的膜包衣。本發明提供製備所述雙層片劑的方法及使用所述雙層片劑治療與SGLT2活性相關的疾病或障礙的方法。