Bhatt, Padmanabh P.,Liang, Likan,Vieira, Michael L.,Wang, Hua
申请号：
ES11179776
公开号：
ES2555066T3
申请日:
2007.11.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A sustained release formulation of topiramate for oral administration to a mammalian subject comprising topiramate as an active ingredient, which is released from the formulation according to a predetermined release profile, said formulation comprising an extended release component (XR), wherein the extended release component is such that it releases topiramate in vivo continuously, wherein said prolonged release component is provided in at least a population of beads coated with a release control coating and characterized by its own release rate, wherein said beads comprise an inert carrier, topiramate, an optional enhancer agent, and a coating that controls release comprising a coating material and a pore former and, optionally, other excipients, wherein said coating material which Control release comprises ethyl cellulose, methylcell ulosa, hydroxypropylcellulose, hydroxypropylmethylcellulose, cellulose acetate, polyvinyl alcohol, polyacrylates, polymethacrylates or copolymers thereof； and said pore former comprises glucose, fructose, mannitol, mannose, galactose, sorbitol, pululane, dextran, water-soluble hydrophilic polymers, hydroxyalkylcelluloses, carboxy-alkylcelluloses, hydroxypropyl methylcellulose, cellulose ethers, acrylic resins, polyvinylpyrrolidone, polyvinyl pyrrolidone oxide Carbowaxes, Carbopol, diols, polyols, polyhydric alcohols, polyalkylene glycols, polyethylene glycols, polypropylene glycols or block polymers thereof, polyglycols, poly ([alpha] - [omega]) alkylenediols； inorganic compounds； alkali metal salts； alkaline earth metal salts, or combinations thereof, wherein said inert carrier is selected from the group consisting of cellulose spheres, silicon dioxide, starch and sugar spheres.Una formulación de liberación sostenida de topiramato para administración oral a un sujeto mamífero que comprende topiramato como ingrediente activo, que es liberado desde la formulación según un perfil de liberación predeterminado, comprendiendo dicha formul
