CRINE, Philippe,BOILEAU, Guy,LOISEL, Thomas P.,LEMIRE, Isabelle,LEONARD, Pierre,HEFT, Robert,LANDY, Hal
申请号：
MEP4814
公开号：
ME01828B
申请日:
2008.05.12
申请国别(地区):
ME
年份:
2014
代理人:
摘要：
A bone targeted alkaline phosphatase comprising a polypeptide having the structure : Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase； wherein V is absent or is an amino acid sequence of at least one amino acid； X is absent or is an amino acid sequence of at least one amino acid； Y is absent or is an amino acid sequence of at least one amino acid； Z is absent or is an amino acid sequence of at least one amino acid； and Wn is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kits and methods of use thereof.text
