Nucleic acid expression constructs are provided and, more particularly, nucleic acid constructs for expression of human alpha-galactosidase in plant cells, cells expressing the nucleic acid construct, producing the human alpha-galactosidase and uses thereof.Linvention concerne des constructions dexpression dacide nucléique et, plus particulièrement, des constructions dacide nucléique pour lexpression dune alpha-galactosidase humaine chez des cellules végétales, des cellules exprimant la construction dacide nucléique, produisant lalpha-galactosidase humaine, et leurs utilisations.