GABIZON ALBERTO A,BARENHOLZ YECHEZKEL,SHMEEDA HILARY
申请号：
IN286/CHENP/2014
公开号：
IN2014CN00286A
申请日:
2014.01.13
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present disclosure provides liposomes comprising a membrane and an intrahposomal aqueous water phase the membrane comprising at least one liposome forming lipid and the intrahposomal aqueous water phase comprises a salt of a bisphosphonate together with an amphipathic weak base agent (PLAD). An example of a liposome is one comprising co encapsulated in the intrahposomal aqueous water phaseN containing bisphosphonate such as alendronate and an anthracycline such as doxorubicin which was shown to increase survival as compared to Doxil or to administrations of liposomal alendronate (PLA) and Doxil (separate liposomes). Such liposomes may carry a targeting moiety exposed at the liposome s outer surface for example conjugate of folic acid as a targeting moiety to folate receptor (FT PLAD). Also provided by the present disclosure is a method of preparing the liposomes and methods of use of the liposomes at times in combination with additional active ingredients such as ?d T cells.
