(2S, 3R, 4R, 5S, 6R) - 2 - (2, 3-dihydro-1h-inden-5-il or 2, 3-dihydrobenzofurano-5-il) - 6 - (hydroximetyl) - tetrahydro-2h-piran-3, 4, 5-trial, sodium glucose conjugated carrier inhibitor (SGLT) in intestine and kidney； It is used to treat diabetes, diabetic complications, obesity and other diseases caused by hyperglycemia.
KIM, Ji Sook,KIM, Won Jeoung,JANG, Wook,SONG, Ji Young,LEE, Moon Sub,KIM, Nam Du,SUH, Kwee Hyun
申请号：
CL2016002870
公开号：
CL2016002870A1
申请日:
2016.11.10
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
<； p >； This Invention Bertalanffy refers to a New derivative BIC & iacute； CLICO has an Inhibitory activity against Sodium - linked glucose Transporters (SGLT) present in the intestines and the Ri & ntilde； ones, or Salt, is & amp； Grouper, hydrate or solvate & pharmaceutical the uticamente aceptab Are the same,And a Pharmaceutical composition & acute； S & eacute； utica comprising the same as an active ingredient, which effectively inhibit the activity of SGLT, and therefore can be used as a Therapeutic Agent & eacute； products for the treatment of diseases caused p <； / p >；La presente invención se refiere a compuestos bicíclicos derivados de (2S,3R,4R,5S,6R)-2-(2,3-dihidro-1H-inden-5-il o 2,3-dihidrobenzofurano-5-il)-6-(hidroximetil)-tetrahidro-2H-piran-3,4,5-triol, inhibidores a transportadores ligados de sodio-glucosa (SGLT) presentes en los intestinos y riñones； composición farmacológica； útiles para el tratamiento de enfermedades causadas por la hiperglucemia, tales como diabetes, complicaciones diabéticas y obesidad.
