The invention discloses chemical synthesis, the effect of the antitumor and anti-metabolism for the dual funtionals being conjugated as being shown by formula I. In detail, taxol or docetaxol and muramyl dipeptide derivative are related to form a cognate, so that the effect of dual antitumor and anti-metabolism is realized by the combination of chemotherapy and immunization therapy. It is described to be conjugated the manufacture that can be used for anti-tumor agents as being proved by reliable bioassay the present invention also discloses the combinatorial compound that taxol or docetaxol and muramyl dipeptide derivative conjugate pass through solid phase and liquid phase synthesis.
