EDDY W. YUE,RICHARD B. SPARKS,ANDREW BUESKING,GE ZOU,NIKOO FALAHATPISHEH,LIXIN SHAO,ANDREW P. COMBS,STACEY SHEPARD,ARTEM SHVARTSBART
申请号：
ARP160103370
公开号：
AR106595A1
申请日:
2016.11.04
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
This application relates to compounds or salts thereof, stereoisomers of pharmaceutically acceptable, which are inhibitors of PI3K - GWhich are useful for the treatment of disorders such as autoimmune diseases, cardiovascular diseases, cancer, and Neurodegenerative Diseases.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt thereof； wherein, x u00b9 and x are each independently c or n,Whenever x u00b9 and x are not simultaneously N； X is n, nr u00b3 u1d43, or cr u00b3； x u2074 is n, nr u2074 u1d43, or cr u2074； x u2075 is n, nr u2075 u1d43, or cr u2075； W is n or CH； y u00b9 is n or cr u00b9 u2070； y u00b2 is n or cr u00b9 u00b9； one of z u00b9 and z u00b2 is n,The other is z u00b9 and z u00b2 C； u207b u207b u207b u207b u207b is a simple link or a link to maintain the Double Ring and Ring B being r u00b9 is H, alkyl Aromatics； c u2081 u208b u2086, alquenilo c u2082 u208b u2086, alquinilo c u2082 u208b u2086,Haloalquilo c u2081 u208b u2086, cycloalkyl or c u2083 u208b u2086 heterocicloalquilo 4 - 10 members, where c u2081 u208b u2086 alquenilo c u2082 u208b u2086, alkyl, cycloalkyl alquinilo c u2082 u208b u2086, haloalquilo c u2081 u208b u2086, c u2083 u208b u2086,And heterocicloalquilo 4 - 10 members are each optionally substituted with 1, 2 or 3 r u02b2 independently Selected substituents； R u00b2 is or u00b9 u00b3, cycloalkyl c u2083 u208b u2086,Heterocicloalquilo 4 - 10 members, c u2086 u208b u2081 u2080 aryl or heteroaryl 5-10 members, where the c u2083 u208b u2086 heterocicloalquilo cycloalkyl, aryl 4 - 10 members, c u2086 u208b u2081 u2080,Heteroaryl and 5 - 10 members of each R u00b2 are optionally substituted with 1, 2, 3, 4, or 5 r u02b2 substituents Selected r u00b3, r u2074, regardless；R u2075 and r u2076 are each independently selected from h, alkyl, Halo, c u2081 u208b u2086, alquenilo c u2082 u208b u2086, alquinilo c u2082 u208b u2086, haloalquilo c u2081 u208b u2086, haloalcoxi c u2081 u208b u2086 c u2086 u208b u2081 u2080 c
