SRPIN340 EN TANT QUE MODULATEUR DU SPLICING DE VEGF ET AGENT ANTI-ANGIOGÉNIQUES

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专利权人:

UNIVERSITY OF BRISTOL

发明人:

申请号：

EP08718670.6

公开号：

EP2146736B1

申请日:

2008.03.10

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.

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中国工程科技知识中心

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http://www.ckcest.cn/home/