Rohan Lalith Wimalasena;Kenneth Robert Wehmeyer;Thomas Massey Burt;Angela Marie Fieno;Gina Marie Fadayel;Patricia West Doyle;James Robert Schwartz;Kathleen Marie Kerr
发明人:
James Robert Schwartz,Kathleen Marie Kerr,Patricia West Doyle,Kenneth Robert Wehmeyer,Thomas Massey Burt,Angela Marie Fieno,Rohan Lalith Wimalasena,Gina Marie Fadayel
申请号：
US12562757
公开号：
US08420054B2
申请日:
2009.09.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal； allowing for adherence of epithelial cells to the adhesive article； removing the adhesive article from the epithelium of the mammal； preparing the adhesive article using standard laboratory methods for extraction； extracting histamine from the epithelial cells adhered to said adhesive article； measuring histamine from the epithelial cells adhered to said adhesive article； determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.
