DALMASES BARJOAN, Pere,HERBERA ESPINAL, Reyes,ALVAREZ LARENA, Angel María
申请号：
DK07857940
公开号：
DK2164848T3
申请日:
2007.12.20
申请国别(地区):
DK
年份:
2016
代理人:
摘要：
Relates to a new polymorphic form of Granisetron base, Form I, to methods for obtaining thereof, to the method for obtaining Granisetron.HCl and its use for preparing pharmaceutical formulations. The Form I is characterized by the X-ray powder diffractogram shown in FIG. 1. Included in summarised form are the methods and solvents for obtaining the Form I: 1) Evaporation of hexane at atmospheric pressure； 2) Evaporation of acetone at atmospheric pressure； 3) Evaporation of toluene at atmospheric pressure； 4) Cooling of a saturated solution of diethyl ether to reflux temperature； 5) Evaporation of 2-propanol atmospheric pressure； 6) Evaporation of tetrahydrofuran at atmospheric pressure； and 7) Cooling of a saturated solution of acetonitrile to reflux temperature.
