ANTISENSE COMPOSITIONS WITH ENTERIC COATING FOR TREATING CROHNS DISEASE, COLITIS AND BOWEL DISEASE

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专利权人:

GIULIANI INTERNATIONAL LIMITED

发明人:

BARONI, SERGIO,BELLINVIA, SALVATORE,VITI, FRANCESCA

申请号：

NZ59267309

公开号：

NZ592673A

申请日:

2009.11.13

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

592673 Provided is a pharmaceutical tablet formulation for oral administration of an antisense oligonucleotide comprising: an intra-granular phase comprising a specified antisense oligonucleotide designed to inhibit SMAD7 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable filler an extra-granular phase comprising a disintegrant and an enteric coating comprising an ethylacrylate-methacrylic acid copolymer. The composition can be used to treat Crohns disease, ulcerative colitis and inflammatory bowel disease.

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