This patent relates to a composition comprising a carrier, oligonucleotides (oligos) that are anti-sense to adenosine receptors, and contain low amounts of or no adenosine (A), and bronchodilating agents. These agents and the composition and formulations provided are suitable for the treatment of respiratory tract, pulmonary and maliugnant diseases associated with bronchoconstriction, respiratory tract inflammation and allergies, impaired airways, including lung disease and diseases whose secondary effects afflict the lungs of a subject, such as allergies, asthma, impeded respiration, allergic rhinitis, pain, cystic fibrosis, pulmonary fibrosis, RDA, COPD, and cancers, among others. The present agents and composition may be administered preventatively, prophylactically or therapeutically in conjunction with other therapies, or may be utilized as a substitute for therapies that have significant, negative side effects.
