MODÈLE MURIN D'INDUCTION DE LA MYOPIE ET INHIBITEUR DE STRESS DU RÉTICULUM ENDOPLASMIQUE POUR PRÉVENIR OU SUPPRIMER LA MYOPIE

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专利权人:

Tsubota Laboratory; Inc.

发明人:

申请号：

EP18764652.6

公开号：

EP3593817A1

申请日:

2018.03.06

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention and suppression agent.

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中国工程科技知识中心

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