SYNTHETIC METHODS FOR PREPARING 3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-{4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL}BENZAMIDE MONO HYDROCHLORIDE, OTHER SALT FORMS OF THIS COMPOUND AND INTERMEDIATES THEREOF
Methods of preparing 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4- methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, methods of preparing other salt forms of said compound, pharmaceutical compositions thereof and methods of use are disclosed herein.Linvention concerne des procédés de préparation de monochlorhydrate de 3-(imidazo [1,2-b] pyridazin-3-yléthynyl)-4-méthyl-N-{4- [(4-méthylpipérazin-1-yl)méthyl]-3-(trifluorométhyl)phényl} benzamide, des procédés de préparation dautres formes de sels de ce composé, des compositions pharmaceutiques de ceux-ci, et des procédés dutilisation.
