A homogeneous pharmaceutical composition comprising cetirizine or a pharmaceutically acceptable salt thereof as antihistamine, a corticosteroid selected from budesonide, ciclesonide, fluticasone, triamcinolone, mometasone and a pharmaceutically acceptable salt of any of these compounds, a polar lipid liposome consisting of a phospholipid or a mixture of phospholipids, a pharmaceutically-acceptable buffer capable of providing a pH of from pH 4 to pH 8 and a pharmaceutically-acceptable aqueous carrier and process for preparation thereof.