PURPOSE: A method for manufacturing a polygonal drug delivery system is provided to effectively and easily prepare the system.CONSTITUTION: A method for manufacturing a polygonal drug delivery system comprises: a step of preparing an outer layer of the system and a step of injecting a drug to the core. A step for preparing the outer layer comprises: a step of forming a pattern on a substrate to prepare a primary mold a step of molding the primary mold to prepare a secondary mold(140) and a step of preparing the outer layer by a stamping method using concavo-convex of the secondary mold. The outer layer contains biodegradable polymers.COPYRIGHT KIPO 2013본 발명은 약물 전달 시스템의 외층을 제조하는 단계 및 상기에서 제조한 외층의 내부 코어(core)에 약물을 주입하는 단계를 포함하는 다면체 형상의 약물 전달 시스템 제조 방법을 개시한다.