This disclosure relates to methods of using 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl} -1,2,3,4-tetrahydroisoquinoline-7-sulfonamide in a disease modifying therapy of Alzheimer’s disease, other tauopathies and related neurodegenerative diseases.本發明係有關一種在阿茲海默症、其他tau蛋白質病變及相關神經退化性疾病之疾病改善療法中使用2-(環己基甲基)-N-{2-[(2S)-1-甲基吡咯啶-2-基]乙基}-1,2,3,4-四氫異喹啉-7-磺醯胺之方法。