能夠結合B7-H3和CD3的雙特異性單價雙抗體及其用途农业专利-农业专业知识服务系统

发明人:: JOHNSON, LESLIE S.,强生　莱斯利,強生　萊斯利,MOORE, PAUL A.,摩尔　保罗,摩爾　保羅,BONVINI, EZIO,波维尼　爱利欧,波維尼　愛利歐,HUANG, LING,黄　玲,黃　玲,SHAH, KALPANA,尚　坎帕纳,尚　坎帕納,ALDERSON, RALPH,安德森　瑞夫,CHICHILI, GURUNADH REDDY,齐齐李　古兰那达瑞,强生莱斯利,強生萊斯利,摩尔保罗,摩爾保羅,波维尼爱利欧,波維尼愛利歐,黄玲,黃玲,尚坎帕纳,尚坎帕納,安德森瑞夫,齐齐李古兰那达瑞

摘要：: The present invention is directed to B7-H3 x CD3 bispecific monovalent diabodies, and particularly, to B7-H3 x CD3 bispecific monovalent Fc diabodies, that are capable of simultaneous binding to B7-H3 and CD3. The invention is also directed to pharmaceutical compositions that contain such bispecific monovalent Fc diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.本發明涉及B7-H3 x CD3雙特異性單價雙抗體，尤其涉及B7-H3 x CD3雙特異性單價Fc雙抗體，其能夠同時結合至B7-H3和CD3。本發明也涉及包含這類雙特異性單價Fc雙抗體的藥物組合物。本發明另外涉及這類雙抗體在治療癌症和其他疾病和病況中的應用的方法。