경북대학교 산학협력단;KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
CHANG YONG MIN,장용민,KIM HEE KYEONG,김희경
申请号：
KR1020180033430
公开号：
KR1020190111376A
申请日:
2018.03.22
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
In a compound having a novel structure, an anti-inflammatory agent, and a matrix metalloproteinase-9 inhibitor comprising the same comprising the same of the present invention, the compound of the present invention has a structure represented by chemical formula 1. In the chemical formula 1, Linker represents *-(CH_2)_x-A-(CH_2)_y-*, x and y each independently represents an integer of any one of 0 to 5, and A represents *-COO-*, *-CO-*, *-CONH-* or *-O-*. The compound of the present invention can inhibit MMP-9 activity that progresses and worsens the inflammatory response at a site of inflammation, thereby being able to be used as an MMP-9 inhibitor.COPYRIGHT KIPO 2020본 발명의 신규한 구조를 갖는 화합물, 이를 포함하는 항염증제 및 기질 금속 단백질분해효소-9 억제제에서, 본 발명의 화합물은 하기 화학식 1로 나타내는 구조를 갖는다.[화학식 1]상기 화학식 1에서,Linker는 *-(CH2)x-A-(CH2)y-*를 나타내고,x 및 y는 각각 독립적으로 0 내지 5 중 어느 하나의 정수를 나타내며,A는 *-COO-*, *-CO-*, *-CONH-* 또는 *-O-*를 나타낸다.
