Общество с ограниченной ответственностью "Асинэкс Медхим." (RU)
发明人:
Казюлькин Денис Николаевич (RU),Пинскер Ольга Александровна (RU),Колячкина Ангелина Викторовна (RU),Лебедева Ольга Владимировна (RU)
申请号：
RU2012102424/04
公开号：
RU2012102424A
申请日:
2012.01.25
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A compound of general formula (I) (I) or any tautomeric form thereof, or a pharmaceutically acceptable salt thereof, wherein each of X, X, X, X, X, Hvybran from N or C Hvybran from N or CH each of X, X, X a and Hnezavisimo selected from N or CH, provided that the fragment can simultaneously contain one or two nitrogen atoms R, R, r and R c is selected from H, alkyl, 6-14-membered aryl, OSalkila, CF, halogen, COOH , SOOSalkil, CONH, CON (Ci ^ alkyl), CN, N (Ci ^ alkyl), 4-14 membered heteroaryl containing at least one heteroatom selected from nitrogen and oxygen R, R, R c is selected from alkyl, halogen, CN at conv Wii that X, XB Healy this case respectively equal to C "A" may represent a single bond or a bridging ethyne moiety Y may represent a single bond or is independently selected from methylene or ethylene bridging fragments moiety Z is independently selected from unsubstituted or substituted at the nitrogen atom heterocycloalkyl, or unsubstituted or substituted cycloalkyl with the proviso that the N (nitrogen) equal to C (carbon): wherein R c is selected from OH, F, OSalkila, NH, NH (alkyl), N (Ci ^ alkyl), CHOH, CON (RR), wherein R, Rmogut independently represent H, alkyl, cycloalkyl, 6-14 membered aryl, 4-14-membered heteroaryl containing at least one heteroatom selected from nitrogen and oxygen iliRmozhet represent the following heterocyclic substituent: wherein Y, Y = H or C Salkil.Rvybran from H, Salk and, cycloalkyl and heterocycloalkyl general structure:, Salkilkarbonila, Stsikloalkalkarbonila, heterocycloalkylcarbonyl general structure:, arylcarbonyl general structure: heteroarylcarbonyl general structure: derivatives of alkyl-, cycloalkyl-, heterocycloalkyl-, aryl- or heteroaryl acetic acids
