The present invention pertains generally to the field of coolants and medical therapy. More particularly, the present invention relates to certain anti-nociceptive agents, such as [((1R,2S,5f?)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester, that are potent and long-acting and selectively cooling for non-keratinized epithelial tissues as compared to keratinized epithelial tissues, and are useful, for example, for the treatment of (e.g., the alleviation of symptoms of the amelioration of) sensory discomfort of non-keratinized stratified epithelial (NKSE) tissue and so for treatment of: sensory discomfort of an ocular surface, an eyelid, a margin of an eyelid, an anterior part of an eyeball, a conjunctiva, a lachrymal system, a pre-corneal film, or a cornea, a lining of the oral cavity, an internal portion of the lips, a pharyngeal surface, an esophageal surface, or an anogenital surface eye discomfort, e.g., caused by extended wear of contact lenses, by eye strain and/or fatigue, by air pollutants, by excessive exposure to the sun, by conjunctivitis, by dry eye syndrome sensory discomfort associated with oral mucositis airway (e.g., larynx, trachea, and/or bronchi) tightness, discomfort in the airways (e.g., larynx, trachea, and/or bronchi), choking, cough, and/or dyspnea, e.g., associated with asthma and/or chronic obstructive pulmonary diseases (COPD).Cette invention relève, de manière générale, du domaine des réfrigérants et de la thérapie médicale. Plus particulièrement, cette invention concerne certains agents anti-nociceptifs, tels que lester isopropylique de lacide [((1R,2S,5R)-2-isopropyl-5-méthyl-cyclohexanecarbonyl)amino]acétique, qui sont puissants et à action longue et refroidissent sélectivement les tissus épithéliaux non kératinisés, comparativement aux tissus épithéliaux kératinisés, et sont utiles, par exemple, pour traiter (à savoir, soulager les symptômes améliorer) linconfort sensoriel du tissu épithélial stratifié no
