The present invention pertains generally to the field of coolants and medical therapy. More particularly the present invention relates to certain anti nociceptive agents such as [((1R 2S 5f?) 2 isopropyl 5 methyl cyclohexanecarbonyl) amino] acetic acid isopropyl ester that are potent and long acting and selectively cooling for non keratinized epithelial tissues as compared to keratinized epithelial tissues and are useful for example for the treatment of (e.g. the alleviation of symptoms of the amelioration of) sensory discomfort of non keratinized stratified epithelial (NKSE) tissue and so for treatment of: sensory discomfort of an ocular surface an eyelid a margin of an eyelid an anterior part of an eyeball a conjunctiva a lachrymal system a pre corneal film or a cornea a lining of the oral cavity an internal portion of the lips a pharyngeal surface an esophageal surface or an anogenital surface eye discomfort e.g. caused by extended wear of contact lenses by eye strain and/or fatigue by air pollutants by excessive exposure to the sun by conjunctivitis by dry eye syndrome sensory discomfort associated with oral mucositis airway (e.g. larynx trachea and/or bronchi) tightness discomfort in the airways (e.g. larynx trachea and/or bronchi) choking cough and/or dyspnea e.g. associated with asthma and/or chronic obstructive pulmonary diseases (COPD).
