Pharmaceutical composition on the basis of phyto-nutrients with increased bioavailability, having anti-tumor activity, and method for producing said composition (alternatives)
A pharmaceutical composition for peroral delivery of phyto-nutrients includes at least one phyto-nutrient from the following series: epigallocatechin-3-gallate, diindolylmethane, genestein, resveratrol, curcumine, and a solubilizer—a polyvinylcaprolactam/polyvinylacetate/polyethyleneglycol graft copolymer with an average molecular mass of 90000-140000 g/mol at a mass ratio of at least one phyto-nutrient and solubilizer of 1/5 to 1/1. The composition can additionally include a pharmaceutically acceptable carrier. The composition may be produced by dissolving the solubilizer in an organic solvent, dissolving at least one phyto-nutrient in the same organic solvent, mixing the resulting solutions, and distilling off the solvent in vacuo. The resulting mixture is heated to 45-50° C. with constant stirring and, after distillation, the product is dried in vacuo. Ethanol, acetone, or isopropanol can be used as the organic solvent. Alternatively, the composition may be produced by dry mixing the powders of the solubilizer and of at least one phyto-nutrient.
