COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE TROUBLES DE L'EMPREINTE GÉNOMIQUE

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专利权人:

University of Connecticut

发明人:

申请号：

EP18886571.1

公开号：

EP3720508A1

申请日:

2018.12.07

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.

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